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KMID : 0613820080180020273
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Journal of Life Science
2008 Volume.18 No. 2 p.273 ~ p.278
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Inhibitory Effects of Green Tea against Squalene Synthase
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Choi Sung-Won
Hur Nam-Yoon
Lee Han-Seung
Baik Moo-Yeol
Lee Jeong-Gyu
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Abstract
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Various biological resources from plants, animals, mushrooms, microorganisms, and foods were tested for the inhibitory activity against squalene synthase (SQS). Among 32 samples, more than one fourths (9 samples) exhibited significant SQS inhibitory activity. Interestingly, SQS inhibitory activity was detected in the samples such as green tea, fermented soybean paste, and plum juice. The SQS inhibitory activity of green tea was not only high but also stable. Its SQS inhibitors were supposed to be catechin derivatives, which have been known to be main bioactive components in green tea. The galloyl catechins showed higher SQS inhibitory activity compared to the nongalloyl catechins. Especially, (-)-epigallocatechin gallate appeared to be strongest inhibitor against squalene synthase .
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KEYWORD
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Squalene synthase, inhibitors, green tea, catechin derivatives
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